Bispecific anti-MUC16 x anti-CD28 antibodies and uses thereof

A group of nucleic acid molecules encoding a bispecific antigen-binding molecule that binds human CD28 and human MUC16, wherein the group of nucleic acid molecules comprises:

• (a) a first nucleic acid molecule encoding a heavy chain variable region (HCVR) comprising HCDR1, HCDR2, HCDR3 domains, respectively, wherein the first nucleic acid molecule comprises the nucleotide sequences of SEQ ID NOs:
• 19, 21, and 23;
• (b) a second nucleic acid molecule encoding a HCVR comprising HCDR1, HCDR2, HCDR3 domains, respectively, wherein the second nucleic acid molecule comprises the nucleotide sequences of SEQ ID NOs:
• 3, 5 and 7;
• and
• (c) a third nucleic acid molecule encoding a light chain variable region (LCVR) comprising LCDR1, LCDR2, LCDR3 domains, respectively, wherein the third nucleic acid molecule comprises the nucleotide sequences of SEQ ID NOs:
• 11, 13 and 15.