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US 12,668,612 B2Granted
Oncolytic non-human adenoviruses and uses thereof
AssigneeAcademisch Ziekenhuis Leiden (H.O.D.N. Lumc)
InventorsRob Cornelis Hoeben, Selas Bots, Vera Kemp
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Abstract
Novel nucleic acid sequences, vectors and adenoviral genomes are provided herein. Corresponding novel adenoviruses and genotypes and compositions are also provided. The novel nucleic acid sequences, vectors, genomes, adenoviruses, genotypes and compositions are useful in therapy. The novel nucleic acid sequences, vectors, genomes, adenoviruses, genotypes and compositions are particularly useful in treating or preventing cancer.
Claims14
An isolated non-human primate adenovirus having a capsid comprising a penton base polypeptide, wherein the penton base polypeptide comprises:
- (i) an amino acid sequence having at least 95% identity to SEQ ID NO:
- 26, or
- (ii) the amino acid sequence of SEQ ID NO:
- 26;
- wherein the adenovirus is conditionally replicative.
2 more elements
Dependencies are inferred from the claim text.