Heterocyclic amide compound, preparation method therefor and use thereof

A compound of formula (IA), an optical isomer thereof or a pharmaceutically acceptable salt thereof,

• wherein,
• L1 is selected from the group consisting of —O—, —NH— and a single bond;
• R1 is selected from the group consisting of H and C1-6 alkyl, wherein the C1-6 alkyl is optionally substituted with 1, 2 or 3 R;
• R2 and R3 are each independently selected from the group consisting of H,
• C3-6 cycloalkyl, 5-6 membered heterocycloalkyl and 5-6 membered heteroaryl, wherein the C3-6 cycloalkyl, 5-6 membered heterocycloalkyl or 5-6 membered heteroaryl is optionally substituted with 1, 2 or 3 R;
• L2 is selected from the group consisting of a single bond, —O—, —S—, —NH— and —NHC(═O)—;
• R4 is selected from the group consisting of
• m is selected from the group consisting of 1, 2, 3, 4, 5 and 6;
• R5 is independently selected from the group consisting of OH, NH2, —CH2NH2,
• R6 and R7 are included in each instance of repeating unit of variable m, and in each instance,
• R6 and R7 are each independently selected from the group consisting of H, halogen, N3, OH, SH, NH2, CN,
• C1-6 alkyl, C1-6 alkoxy, C1-6 alkylthio and C1-6 alkylamino, wherein the C1-6 alkyl, C1-6 alkoxy, C1-6 alkylthio or C1-6 alkylamino is optionally substituted with 1, 2 or 3 R;
• R8 is selected from the group consisting of H, halogen, N3, OH, SH, NH2, CN,
• and C1-6 alkyl, wherein the C1-6 alkyl is optionally substituted with 1, 2 or 3 R;
• or, R3 and R8 are linked to form a 5-6 membered heterocyclic ring;
• R9 and R12 are each independently selected from the group consisting of H and C1-6 alkyl, wherein the C1-6 alkyl is optionally substituted with 1, 2 or 3 R;
• R10, R11, R13 and R14 are each independently selected from the group consisting of H, halogen, N3, OH, SH, NH2, CN and C1-6 alkyl, wherein the C1-6 alkyl is optionally substituted with 1, 2 or 3 R;
• or, R9 and R13 are linked to form a carbon chain comprising 3-7 carbon atoms;
• T is selected from the group consisting of N and CH;
• R is independently selected from the group consisting of H, halogen, N3, OH, SH, NH2, CN,
• C1-6 alkyl, C1-6 alkoxy, C1-6 alkylthio, C1-6 alkylamino, 5-6 membered heterocycloalkyl, phenyl and 5-10 membered heteroaryl, wherein the C1-6 alkyl, C1-6 alkoxy, C1-6 alkylthio, C1-6 alkylamino, 5-6 membered heterocycloalkyl, phenyl or 5-10 membered heteroaryl is optionally substituted with 1, 2 or 3 R′;
• R′ is selected from the group consisting of H, F, Cl, Br, I, OH, NH2 and CH3;
• the 5-6 membered heterocycloalkyl, 5-6 membered heteroaryl, 4-10 membered heterocycloalkyl or 5-10 membered heteroaryl contains 1, 2 or 3 heteroatoms or heteroatom groups independently selected from the group consisting of —O—, —NH—, —S— and N.