Heteroaryl compounds as inhibitors of RIP2 kinase, composition and application thereof

A compound of Formula (I):

• or a pharmaceutically acceptable salt, ester, solvate, prodrug, isotope-labeled derivative, stereoisomer or tautomer thereof, wherein:
• n is 0, 1, 2 or 3;
• L is a bond, —O—, —N(R6)—, or
• wherein # denotes a connection to R3;
• ring A is C6-10 aryl and 5-10 membered heteroaryl;
• R1 is independently H, deuterium, halide, —OH, amino, —CN, C1-6 alkyl, C3-6 cycloalkyl, —O(C1-6 alkyl), —NH(C1-6 alkyl), —N(C1-6 alkyl)2, C2-6 alkenyl or C2-6 alkynyl, wherein C1-6 alkyl, C3-6 cycloalkyl, C2-6 alkenyl and C2-6 alkynyl are unsubstituted or substituted with 1 to 3 groups independently selected from Ra;
• R2 is independently H, deuterium, C1-3 alkyl or C3-6 cycloalkyl, wherein C1-3 alkyl and C3-6 cycloalkyl are unsubstituted or substituted with 1 to 3 groups independently selected from Rb;
• R3 is independently H, halide, —OH, amino, C1-6 alkyl, C3-6 cycloalkyl, —O(C1-6 alkyl), 3-6 membered cycloheteroalkyl, C6-10 aryl or 5-10 membered heteroaryl, wherein C1-6 alkyl, C3-6 cycloalkyl, 3-6 membered cycloheteroalkyl, C6-10 aryl and 5-10 membered heteroaryl are unsubstituted or substituted with 1 to 3 groups independently selected from Rc;
• R4 is C1-3 alkyl, wherein C1-3 alkyl is unsubstituted or substituted with 1 to 3 groups independently selected from Rd,
• R5 is C1-3 alkyl, wherein C1-3 alkyl is unsubstituted or substituted with 1 to 3 groups independently selected from Re,
• or R4 and R5 together with the phosphorus atom attached thereto form 5-6 membered cycloheteroalkyl or 5-8 members cycloheteroalkenyl, wherein 5-6 membered cycloheteroalkyl and 5-8 members cycloheteroalkenyl are unsubstituted or substituted with 1 to 3 groups independently selected from Rd,
• R6 is H, C1-3 alkyl, or C3-6 cycloalkyl, wherein C1-3 alkyl and C3-6 cycloalkyl are unsubstituted or substituted with 1 to 3 groups independently selected from Rf,
• R7 is independently H, deuterium, F, Cl, Br, —OH, amino, —CN, C1-6 alkyl, C3-6 cycloalkyl, —O(C1-6 alkyl), —NH(C1-6 alkyl), —N(C1-6 alkyl)2, C2-6 alkenyl or C2-6 alkynyl, wherein C1-6 alkyl, C3-6 cycloalkyl, C2-6 alkenyl and C2-6 alkynyl are unsubstituted or substituted with 1 to 3 groups independently selected from Ra,
• Ra, Rb, Rd, Re and Rf are independently F, Cl, Br, I, —OH, amino, methyl or methoxy;
• and
• Rc is independently deuterium, F, Cl, Br, I, —OH, amino, methyl, methoxy or
• wherein each of 3-6 membered cycloheteroalkyl 5-6 membered cycloheteroalkyl, 5-8 members cycloheteroalkenyl, and 5-10 membered heteroaryl comprises 1 to 3 heteroatoms or heteroatom groups independently selected from N, NH, O, S and P(═O).