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US 12,668,599 B2Granted
Heterobifunctional compounds and methods of treating disease
AssigneeHalda Therapeutics OpCo, Inc.
InventorsKyle J. Eastman, Katherine J. Kayser-Bricker, James John Mousseau, Kanak Shail Raina
Life of this patent
Estimating the term…
Abstract
The invention provides heterobifunctional compounds, pharmaceutical compositions, and their use treating disease, such as cancer.
Claims30
A compound represented by Formula It or Iv, or a pharmaceutically acceptable salt thereof:
- wherein
- L is one of the following:
- (i)-(7-11 membered spirocyclic or fused bicyclic saturated heterocyclic ring containing 1, 2, or 3 heteroatoms independently selected from nitrogen and oxygen)-O-***, wherein *** is the point of attachment to the phenylene group in said formula;
- (ii) a 7-11 membered spirocyclic or fused bicyclic saturated heterocyclic ring containing 1, 2, or 3 heteroatoms independently selected from nitrogen and oxygen;
- or
- (iii)-(7-11 membered spirocyclic saturated heterocyclic ring containing 1 or 2 heteroatoms selected from nitrogen)-(C2-4 alkynylene)-***, wherein *** is the point of attachment to the phenylene group in said formula;
- and
- t is 0 or 1.
5 more elements
A compound represented by:
- or a pharmaceutically acceptable salt thereof.
A compound selected from the following or a pharmaceutically acceptable salt thereof:
Dependencies are inferred from the claim text.