MK2 inhibitors and uses thereof

A compound of formula I:

• or a pharmaceutically acceptable salt thereof, wherein:
• Ring A is a 5-6 membered heteroaryl ring having 1-3 heteroatoms independently selected from nitrogen, oxygen, and sulfur, provided that when Ring A is a 6-membered heteroaryl ring the 1-3 heteroatoms are each nitrogen;
• each R1 and R1′ is independently selected from -hydrogen and C1-4 aliphatic substituted with 0-3 instances of Rx, or:
• R1 and R1′ may, together with the intervening atoms to which they are attached, form an optionally substituted 3- to 6-membered saturated, or partially unsaturated, heterocyclyl, carbocycle, or aryl ring having 0-3 heteroatoms independently selected from nitrogen, oxygen, and sulfur;
• Rx is —CN, —NO2, halogen, —OR, —SR, —N(R)2, —C(O)N(R)2, —C(O)OR, —C(O)R, —N(R)C(O)R, —SO2N(R)2, or —N(R)SO2;
• R2 is —CN, C2-6 aliphatic substituted with m instances of Ry, wherein the C2-6 aliphatic has at least one unit of unsaturation, or R2 is selected from the group consisting of
• each Ry is independently selected from D, halogen, —CN, —CO2R, —N(R)2, and a 3- to 6-membered saturated or partially unsaturated heterocyclic ring having 1-3 heteroatoms independently selected from nitrogen, oxygen, and sulfur;
• each R3 is —(CH2)r-Cy, or R3 is selected from the group consisting of
• each R4 is independently selected from hydrogen, C1-6 aliphatic, and —Cy, wherein the C1-6 aliphatic is optionally substituted with one or more substituents each independently selected from D, halogen and —OR;
• each R5 is independently selected from —OR and —Cy;
• each Cy is independently a ring selected from a 3- to 9-membered saturated or partially unsaturated monocyclic carbocyclic ring, a 3- to 9-membered saturated or partially unsaturated monocyclic heterocyclic ring having 1-3 heteroatoms independently selected from nitrogen, oxygen, and sulfur, phenyl, a 5- to 6-membered heteroaryl ring having 1-3 heteroatoms independently selected from nitrogen, oxygen, and sulfur, a 7- to 12-membered saturated or partially unsaturated fused, spirofused, or bridged bicyclic carbocyclic ring, or a 7- to 12-membered saturated or partially unsaturated fused, spirofused, or bridged bicyclic heterocyclic ring having 1-3 heteroatoms independently selected from nitrogen, oxygen, and sulfur, wherein the ring is optionally substituted with one or more substituents each independently selected from D, halogen, oxo, R, and —(CH2)q—OR;
• each R is independently hydrogen or a C1-6 aliphatic optionally substituted with one or more substituents each selected from D, halogen, —OH, and —O—(C1-6 aliphatic), or:
• two R groups on the same nitrogen are taken together with the nitrogen to form a 3-7 membered saturated or partially unsaturated heterocyclic ring having 1-3 heteroatoms selected from nitrogen, oxygen, or sulfur;
• n is 0;
• each of q, and r is independently 0-4;
• and
• tis 1-4.