N-formamidopyrazoline derivative as P2X3 receptor antagonist and use thereof

An N-formamidopyrazoline compound of General Formula (I), or an enantiomer, a diastereomer, a racemate thereof, or a pharmaceutically acceptable salt thereof:

• wherein
• Ar is selected from 1,3-benzodioxole;
• or Ar is selected from the following substituted phenyls, substitute five-membered or six-membered heteroaromatic ring groups:
• R5 and R6 are independently selected from the group consisting of H, halogen, nitryl, cyano group, methyl, trifluoromethyl, trifluoromethoxy, and C1 to C3 straight or branched chain alkoxy;
• and
• R7 is selected from methyl, ethyl, isopropyl, and cyclopropyl;
• R1 is selected from substituted or unsubstituted phenyl or substituted or unsubstituted pyridyl, wherein R1 is substituted with a group selected from halogen, C1 to C3 straight or branched chain alkyl, C1 to C3 straight or branched chain alkoxy, trifluoromethyl and trifluoromethoxy;
• and R2 is selected from a methyl, an ethyl, an isopropyl and a cyclopropyl;
• and
• wherein the R3 and the R4 are each independently selected from H, methyl, ethyl, methoxycarbonyl, ethoxycarbonyl, propoxycarbonyl, isopropoxycarbonyl, tert-butoxycarbonyl, formyl, acetyl, and N,N-dialkylaminoacetyl;
• or the R3 and the R4 together with the N to which they both are connected form substituted or unsubstituted morpholinone, substituted or unsubstituted morpholinyl, substituted or unsubstituted piperidinyl, substituted or unsubstituted piperazinyl, substituted or unsubstituted piperazinone, substituted or unsubstituted pyrrolidone, substituted or unsubstituted oxazolidinone, substituted or unsubstituted imidazolidinone, substituted or unsubstituted imidazolyl, substituted or unsubstituted pyrazolyl, 1,2,3-triazolyl, and 1,2,4-triazolyl;
• and
• wherein substituted groups on morpholinone, morpholinyl, piperidinyl, piperazinyl, piperazinone, pyrrolidone, oxazolidinone, imidazolidinone, imidazolyl and pyrazolyl are selected from C1 to C3 straight or branched chain alkyl, formyl, acetyl, and C1 to C5 straight or branched chain alkoxy.