Heterocyclic compounds as kinase inhibitors for therapeutic uses

A compound of formula I:

• wherein
• A is H or C1-C6 alkyl;
• Y1 is phenyl substituted with (R1)n, in which R1 in (R1)n, n being 1-4, is, independently, F, Cl, Br, NO2, CN, amino, C1-C6 alkyl, C1-C6 haloalkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C8 cycloalkyl, 5- to 15-membered heterocycloalkyl, carbonyl, thionyl, iminyl, or spiroamino, and at least one R1 is amino or 5- to 15-membered heterocycloalkyl;
• X1 is N;
• X2 is O;
• Y2 is
• in which each of Q1, Q2, Q3, Q4, Q5, Q6, Q7, and Q8 is, independently, N or CR4, R4 being H, F, Cl, Br, CN, amino, C1-C6 alkyl, C1-C6 haloalkyl, or C1-C6 alkoxyl;
• Z1 is O, S, or NRr, Rr being H or C1-C6 alkyl;
• Z2 is O, S, or NRr;
• and G and H are, respectively, C or N and N or C;
• X3 is deleted, CH2, (CH2)2, or CH(C≡CH);
• Y3 is C1-C6 alkyl, aryl, heteroaryl, C3-C8 cycloalkyl, or C5-C6 heterocycloalkyl having one heteroatom, in which the one heteroatom is O or N;
• and
• X4 in (X4)m, m being 0-5, is, independently, F, Cl, Br, CN, SO2NH2, amino, C1-C6 alkyl, C1-C6 haloalkyl, or C1-C6 alkoxyl.