Pyrazolamide derivative, preparation method therefor, and application thereof
AssigneeShenzhen Zhongge Biological Technology Co., Ltd.
InventorsHuimin Cheng, Xiaoming Wen, Peiyu Zhang, Zhiqiang Liu, Lan Luo, Lipeng Lai, Jian Ma, Shuhao Wen
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Abstract
The present invention relates to a compound of chemical Formula (I), a preparation method therefor, and an application thereof, as well as a pharmaceutical composition comprising the compound as an active ingredient, or a pharmaceutically acceptable salt thereof. The present invention further relates to a use of the compound of Formula (I) in the treatment and prevention of EP4-mediated diseases.
Claims10
A compound of Formula I or a pharmaceutically acceptable salt, a hydrate, a solvate, a stereoisomer, an isotopic compound or a prodrug thereof;
- wherein,
- R1 and R2 are each independently selected from the group consisting of:
- H, unsubstituted or halogen-substituted C1-C4 alkyl;
- or R1 and R2 form a C3-C6 cycloalkyl together with the carbon atom to which they are connected;
- R3 is unsubstituted or halogen-substituted C1-C4 alkyl;
- R4 is unsubstituted or halogen-substituted C1-C4 alkyl;
- R5 is selected from the group consisting of:
- hydrogen, halogen, C1-C4 alkyl and C1-C4 alkoxy;
- and
- R6 is absent or selected from the group consisting of:
- halogen, unsubstituted or halogen-substituted C1-C4 alkyl, and unsubstituted or halogen-substituted C1-C4 alkoxy,
- X is O.
Dependencies are inferred from the claim text.