Adamantanyl-substituted benzamide compounds and their use as P2X7 receptor antagonists

A compound of the general formula (I):

• or a pharmaceutically acceptable salt, hydrate, derivative, solvate, or tautomer thereof, wherein:
• R1, R2 and R3 are independently selected from the group consisting of:
• hydrogen, hydroxy and halogen;
• n is an integer between 0 and 4;
• X is selected from the group consisting of:
• NH, O and S;
• R is:
• wherein each R4 is independently selected from the group consisting of:
• halogen, hydroxy, methoxy and amino;
• and
• m is 2,
• with the proviso that at least one of R1, R2 and R3 is F.