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US 12,668,566 B2Granted
Preparation method for salicylamine acetate
AssigneeTSI Group Co., Ltd.
InventorsLing Long, Jianyi Ma, Weiguo Liu, Zhouya Liu
Life of this patent
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Abstract
A preparation method for salicylamine acetate, comprising preparing an amino-protected intermediate from salicylaldehyde, and reacting the intermediate with acetic acid to prepare an acetate.
Claims9
A method for preparing salicylamine acetate, wherein the method comprises the following steps:
- (1) subjecting salicylaldehyde having a structure shown in Formula 1
- to amino protection to obtain a compound having a structure shown in Formula 2
- (2) reacting the compound having the structure shown in Formula 2 with acetic acid to obtain salicylamine acetate in one step, wherein the ratio of the compound of Formula 2 to acetic acid in step (2) is 1:1-20 (g/ml) and the temperature for reacting with acetic acid in step (2) is from 70° C. to the reflux temperature of acetic acid.
Dependencies are inferred from the claim text.