Vacuum-assisted electroporation devices, and related systems and methods

A device for vacuum-assisted in vivo electroporation of tissue, comprising:

• a housing defining a chamber, at least one opening into the chamber at a distal end of the housing, an interior surface located within the chamber, and an end surface within the chamber and located opposite the opening;
• at least one port extending through the housing, wherein the at least one port is remote from the at least one opening and is connectable to a vacuum source, such that the at least one port is configured to communicate vacuum pressure from the vacuum source to the chamber;
• and
• a plurality of electrodes positioned within the chamber, wherein the plurality of electrodes are configured to deliver one or more electroporation pulses to a targeted portion of tissue extending through the at least one opening and at least momentarily held in the chamber responsive to the vacuum pressure, wherein the plurality of electrodes comprises:
• a first electrode that extends along the interior surface and is elongate in a circumferential direction along a circumference of the interior surface, wherein the first electrode is spaced from a proximal end of the chamber;
• and
• a second electrode that extends from the end surface, wherein the first and second electrodes are concentric with each other.