Therapeutic treatment device with braided microvalve occluder

A therapeutic device for delivery of a therapeutic agent within a vessel of a patient during a vascular procedure, the vessel having a vessel wall, comprising:

• a) a flexible catheter sized for introduction into the vessel, the catheter having a proximal end and a distal end, an outer surface, a lumen extending between the proximal and distal ends and opening at a distal orifice;
• and
• b) a filamentary construct mounted on the outer surface of the catheter adjacent the distal end of the catheter, the construct comprising,
• i) a plurality of elastic filamentary strands in a tubular braid extending from a proximal end to a distal end, the plurality of elastic filamentary strands having proximal portions, central portions, and distal portions,
• the distal portions extend from the central portions distally and taper to the distal end of the tubular braid, the distal end longitudinally fixed to the outer surface of the catheter at a first location proximal of the distal orifice,
• the central portions extending proximally from the distal portions and biased to extend radially outward from the outer surface of the catheter, and
• the proximal portions inverting relative to the central portions to extend distally and radially inward onto the outer surface, and coupled circumferentially about the outer surface of the catheter at a second location proximally displaced from the first location, and
• ii) a material provided onto the proximal portions of the plurality of elastic filamentary strands and at least a portion of the central portions of the plurality of elastic filamentary strands, the material forming a barrier to passage of the therapeutic agent.