Nitric oxide generating systems
AssigneeNOTA Laboratories, LLC
InventorsGlenn Martin, Aurora L. Fernandez DeCastro, Mark E. Meyerhoff
Life of this patent
Estimating the term…
Abstract
An example of a nitric oxide (NO) generating system includes an NO generating formulation, having: a stable NO donor/adduct; a hydrophilic binder; and an additive. The additive is to control a rate of release of NO from the stable NO donor/adduct after the formulation is exposed to an effective amount of water, water vapor, or blue or ultraviolet (UV) light. This example NO generating system further includes an inhalation device in operative contact with the NO generating formulation.
Claims9
A nitric oxide (NO) generating system, comprising:
- an NO generating formulation, including:
- an S-nitrosothiol (RSNO) powder present in an amount ranging from about 3 wt % to about 12 wt % of the NO generating formulation;
- a hydrophilic binder present in an amount ranging from about 15 wt % to about 82 wt % of the NO generating formulation;
- a lubricant present in an amount ranging from about 1 wt % to about 15 wt % of the NO generating formulation;
- and
- an additive present in an amount ranging from about 3 wt % to about 60 wt % of the NO generating formulation;
- wherein the additive is to control a rate of release of NO from the NO donor/adduct after the formulation is exposed to an effective amount of water, water vapor, or blue or ultraviolet (UV) light;
- and
- an inhalation device in operative contact with the NO generating formulation.
A nitric oxide (NO) generating system, comprising:
- a moisture activated NO generating formulation, including:
- a stable NO donor/adduct;
- a hydrophilic binder selected from the group consisting of polyvinyl acetate (PVA), poly(ethylene glycol) (PEG), polyacrylamide, acetates, polyethylene oxide (PEO), poly ethyl acrylate (PEA), polyvinylpyrrolidone, polyvinyl pyrrolidone-vinyl acetate (PVP-VA), hydroxypropyl cellulose (HPC), hydroxypropyl methylcellulose (HPMC), microcrystalline cellulose, corn starch, and combinations thereof;
- and
- an additive;
- wherein the additive is to control a rate of release of NO from the NO donor/adduct after the formulation is exposed to water vapor;
- and
- an inhalation device in operative contact with the moisture activated NO generating formulation, wherein the inhalation device is a face mask including a housing to hold the moisture activated NO generating formulation;
- and wherein:
- the moisture activated NO generating formulation is a single solid;
- the housing includes a door;
- and
- one of:
- the single solid is to be snapped in place in the door;
- or
- the single solid is to be slid into a receptacle defined in the door.
A nitric oxide (NO) generating system, comprising:
- a moisture activated NO generating formulation, including:
- a stable NO donor/adduct;
- a hydrophilic binder selected from the group consisting of polyvinyl acetate (PVA), poly(ethylene glycol) (PEG), polyacrylamide, acetates, polyethylene oxide (PEO), poly ethyl acrylate (PEA), polyvinylpyrrolidone, polyvinyl pyrrolidone-vinyl acetate (PVP-VA), hydroxypropyl cellulose (HPC), hydroxypropyl methylcellulose (HPMC), microcrystalline cellulose, corn starch, and combinations thereof;
- and
- an additive;
- wherein the additive is to control a rate of release of NO from the NO donor/adduct after the formulation is exposed to water vapor;
- and
- an inhalation device in operative contact with the moisture activated NO generating formulation;
- wherein the additive is ascorbyl palmitate, and the ascorbyl palmitate is present in an amount ranging from about 3 wt % to about 60 wt % of the moisture activated NO generating formulation.
Dependencies are inferred from the claim text.