Capsule inhalers and methods of using same

A capsule inhaler, comprising:

• a main body comprising an inner cavity, a backwall, and at least one air intake port, wherein the inner cavity is sized and configured to receive a capsule containing a dry powder formulation;
• a mouth section coupled to or integral with the main body and in fluid communication with the inner cavity;
• an actuator coupled to the main body, the actuator comprising an elongate member attachable to an end portion of the capsule, wherein the actuator is configured to move between first and second positions to separate the capsule within the inner cavity;
• at least four longitudinally spaced apart nozzles residing within the main body and in fluid communication with the inner cavity, wherein each of the nozzles extends between the inner cavity and backwall of the main body and opposite the mouth section terminating adjacent to, but spaced apart from, the backwall leaving a gap between the nozzles and the backwall;
• and
• a cover coupled to the main body,
• wherein one or more of the inner cavity, elongate member, and cover each are configured to engage with the capsule when inserted into the inner cavity and assist in separating the capsule to release the dry powder formulation into the inner cavity of the inhaler for inhalation by a subject, and
• wherein at least two of the nozzles are positioned and configured to direct airflow received from the at least one air intake port into separated segments of the capsule and at least another two of the nozzles are positioned and configured to direct bypass airflow received from the at least one air intake port into the inner cavity.