Biomaterial comprising a resorbable porous matrix and associated manufacturing method

A method for manufacturing a biomaterial, comprising:

• a supply of a resorbable porous matrix formed from a material comprising collagen, the resorbable porous matrix being a haemostatic sponge, and exhibiting an inner volume and an outer surface, a hydration of the haemostatic sponge so as to balance pH and osmolarity of the haemostatic sponge, a drying of the haemostatic sponge after the hydration of the haemostatic sponge, after drying the haemostatic sponge, a first seeding of the resorbable porous matrix haemostatic sponge by at least one first type of living biological cells of a tissue, after the first seeding, a cell growth of the at least one type of biological cells, after the first seeding by said at least one first type of biological cells, a drying of the haemostatic sponge, and following said drying, a second seeding of the haemostatic sponge by at least one second type of biological cells, distinct from the at least one first type of biological cells, after the second seeding, a cell growth of the at least one second type of biological cells, a hydration of the resorbable porous matrix so as to balance pH and osmolarity of the resorbable porous matrix, prior to the seeding, and a drying of the resorbable porous matrix between the hydration of the resorbable porous matrix and the seeding of the resorbable porous matrix to form a biomaterial, the biomaterial comprising:
• the resorbable porous matrix haemostatic sponge, and the at least one first and the at least one second types of living biological cells of a tissue disposed in the inner volume and alternatively or complementarily on the outer surface of the resorbable porous matrix haemostatic sponge, and wherein the hydration and the subsequent dryings prior to the first and second seedings condition the haemostatic sponge to promote cell adhesion and subsequent cell growth.