Radioactively labeled ligand for fibroblast activation protein-alpha imaging agent and preparation method therefor
AssigneesFive Eleven Pharma Inc., Biomolecular Probes Biotechnology (Beijing) Co., Ltd
InventorsHank F Kung, Zhihao Zha, Karl Ploessl, Seok Rye Choi, David Alexoff
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Abstract
A radioactively labeled ligand for a fibroblast activation protein-alpha imaging agent and a preparation method therefor are provided. The radioactively labeled ligand for the fibroblast activation protein-alpha imaging agent has structural formal (I). The compound has a good 68Ga labeling property, a high stability and a good affinity for FAP tumors. The radioactively labeled ligand for 68Ga-labeled FAPi can be used as a tumor positron imaging agent.
Claims7
A radioactively labeled ligand for fibroblast activation protein-alpha (FAP) imaging agent, having a structural formula of
- wherein R is —OH or
A radioactively labeled fibroblast activation protein-alpha (FAP) imaging agent, having a structural formula of 68GaA1 or 68GaA2:
Dependencies are inferred from the claim text.