Back to results
US 12,667,609 B2Granted
Recombinant fusion protein vaccine containing Clostridioides difficile FliC and FliD
AssigneeUniversity of South Florida
InventorXingmin Sun
Life of this patent
Estimating the term…
Abstract
A novel vaccine and methods of preventing and treating C. difficile infection in a patient is described. The vaccine is comprised of a fusion protein (denoted FliCD) comprised of the FliC and FliD from C. difficile and joined by a linker sequence. Administration of the vaccine, as well as anti-FliCD serum, has been shown to prevent C. difficile infection as well as treat existing infections.
Claims2
A fusion protein comprising:
- a portion of at least one flagellin protein (FliC) from a Gram-positive bacterium;
- and
- a portion of at least one cap protein (FliD) from a Gram-positive bacterium;
- wherein the Gram-positive bacterium is from the genus Clostridioides;
- wherein the fusion protein has a sequence of SEQ ID NO:
- 7.
3 more elements
Dependencies are inferred from the claim text.