Immunotherapeutic nanoparticles and methods relating thereto
AssigneeWake Forest University Health Sciences
InventorsDawen Zhao, Yang Liu, Neil William Crowe
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Abstract
Compositions containing lipid nanoparticles and nucleic acid therapeutic agents are disclosed. For example, calcium phosphate nanoparticles having a lipid coating are provided, wherein the calcium phosphate nanoparticles include a cyclic dinucleotide and the lipid coating includes phosphatidylserine. The compositions can be formulated for administration to the lungs of a subject via inhalation, or for administration via injection. Methods for the treatment of lung cancer and other cancers are also described. Targeted delivery of therapeutic agents such as cyclic dinucleotides to antigen presenting immune cells via the disclosed methods can elicit beneficial antitumor immunity.
Claims15
A composition comprising a calcium phosphate nanoparticle having a lipid coating, wherein the lipid coating comprises a bilayer containing anionic phosphatidylserine, a phosphatidylcholine, and a sterol, wherein the anionic phosphatidylserine is present in both layers of the bilayer, wherein the calcium phosphate nanoparticle targets antigen presenting cells, and wherein the composition can be used as an inhalable nanoparticle immunotherapy that can be aerosolized during use, wherein the calcium phosphate nanoparticle comprises a nucleic acid therapeutic agent, and wherein the nucleic acid therapeutic agent is 2′3′ cyclic guanosine monophosphate-adenosine monophosphate (2′3′ cGAMP).
A liquid composition comprising a calcium phosphate nanoparticle having a lipid coating, wherein the lipid coating comprises a bilayer containing anionic phosphatidylserine, phosphatidylcholine, and a sterol, wherein the anionic phosphatidylserine is present in both layers of the bilayer, wherein the calcium phosphate nanoparticle targets antigen presenting cells, wherein the liquid composition can be aerosolized prior to administration, wherein the calcium phosphate nanoparticle comprises a nucleic acid therapeutic agent, and wherein the nucleic acid therapeutic agent is 2′3′ cyclic guanosine monophosphate-adenosine monophosphate (2′3′ cGAMP).
Dependencies are inferred from the claim text.