Retinoic acid precursor and anticancer drug composition comprising same
AssigneeIndustrial Cooperation Foundation Jeonbuk National University
InventorsDong Won Lee, Eun Kyeong Jung
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Abstract
A retinoic acid prodrug to which a boron functional group having a structure represented by chemical formula 1 is bound is described. The retinoic acid prodrug self-assembles to form nanoparticles. Therefore, an anticancer drug composition comprises the same as an active ingredient. According to the retinoic acid prodrug, targeted therapy of tumor cells is possible through the synergistic anticancer effect of retinoic acid and the boron functional group and the surface modification of particles. In particular, the retinoic acid prodrug enables a drug loading of 100 wt %, and thus can provide an effective anticancer drug.
Claims11
A retinoic acid prodrug (RABA) comprising:
- a boron functional group, wherein the RABA has a structure represented by Formula 1:
Dependencies are inferred from the claim text.