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US 12,667,544 B2Granted
Microspheres containing therapeutic agents and related methods of use
AssigneeBiosphere Medical, Inc.
InventorPhilippe Reb
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Abstract
Microspheres, compositions including the microspheres, and methods of using the microspheres are disclosed herein. The microspheres can be substantially spherical and can include a copolymer of a monomer (such as an acrylic monomer) and a cyclodextrin or a derivative thereof. The microspheres can also include a therapeutic agent, such as a platinum-based drug.
Claims18
A method of embolization, comprising:
- administering to a patient microspheres comprising:
- a biocompatible, cross-linked polymeric material comprising a copolymer comprising at least one of an acrylic monomer, an acrylamide monomer, or a vinyl monomer, and a cross-linking agent, wherein the polymeric material is dispersed throughout a polymer matrix that forms each of the microspheres;
- a biodegradable portion comprising a cyclodextrin;
- a non-biodegradable portion that is cross-linked;
- and
- a therapeutic agent,
- wherein the microspheres have an average diameter of from about 10 μm to about 2,000 μm;
- occluding a blood vessel with the microspheres before the therapeutic agent has been released from the microspheres;
- releasing the therapeutic agent into the blood vessel from the microspheres as the biodegradable portion of the microspheres including the cyclodextrin biodegrades in the blood vessel;
- and
- occluding the blood vessel with the microspheres after degradation of the biodegradable portion and release of the therapeutic agent into the blood vessel, the non-biodegradable portion retaining a substantially spherical shape after degradation of the biodegradable portion and decreasing blood flow through the occluded blood vessel by more than 80% after the therapeutic agent has been released and after the biodegradable portion has been degraded.
8 more elements
A method of embolization, comprising:
- administering to a patient microspheres comprising:
- a biocompatible, cross-linked polymeric material comprising a copolymer comprising an acrylamide monomer and an acrylamide cross-linking agent, wherein the polymeric material is dispersed throughout a body of each of the microspheres that includes an inner region and an outer region of a polymer matrix forming each of the microspheres;
- a biodegradable portion comprising a cyclodextrin;
- a non-biodegradable portion that is cross-linked;
- and
- a therapeutic agent comprising a platinum-based drug, wherein the microspheres comprise 10 to 100 mg of the therapeutic agent per 50 to 200 mg of dried microspheres,
- wherein the microspheres have an average diameter of from about 10 μm to about 2,000 μm;
- occluding a blood vessel with the microspheres before the therapeutic agent has been released from the microspheres;
- releasing the therapeutic agent into the blood vessel from the microspheres as the biodegradable portion of the microspheres including the cyclodextrin biodegrades in the blood vessel;
- and
- occluding the blood vessel with the microspheres after degradation of the biodegradable portion and release of the therapeutic agent into the blood vessel, the non-biodegradable portion retaining a substantially spherical shape after degradation of the biodegradable portion and decreasing blood flow through the occluded blood vessel by more than 80% after the therapeutic agent has been released and after the biodegradable portion has been degraded.
8 more elements
Dependencies are inferred from the claim text.