Pulse control method and apparatus, ablation device and system, and storage medium

A pulse control apparatus, comprising:

• an electric pulse control module configured to control a pulse generator to output a nanosecond pulse sequence and control the pulse generator to output a millisecond pulse sequence;
• and
• control an amplitude of the nanosecond pulse sequence to be greater than a preset first threshold voltage and control an amplitude of the millisecond pulse sequence to be less than a preset second threshold voltage, and
• wherein the nanosecond pulse sequence causes irreversible electroporation to occur in cells close to an electrode needle such that the cells enter an apoptosis process, and causes reversible electroporation to occur in cells relatively far from the electrode needle;
• wherein the millisecond pulse sequence causes intracellular electrolysis of the cells relatively far from the electrode needle in which reversible electroporation occurs, such that the cells relatively far from the electrode needle also enter the apoptosis process.

An ablation device, comprising:

• an electrode needle configured to contact a target object and output an electric pulse to the target object, the electric pulse comprising a nanosecond pulse sequence and a millisecond pulse sequence;
• a pulse generator electrically connected to the electrode needle and configured to generate the electric pulse and conduct the electric pulse to the electrode needle;
• and
• a controller communicatively connected with the pulse generator and configured to perform a pulse control method comprising:
• controlling the pulse generator to output the nanosecond pulse sequence, and
• controlling the pulse generator to output the millisecond pulse sequence,
• wherein an amplitude of the nanosecond pulse sequence is greater than a preset first threshold voltage, and an amplitude of the millisecond pulse sequence is less than a preset second threshold voltage, and
• wherein the nanosecond pulse sequence causes irreversible electroporation to occur in cells close to the electrode needle such that the cells enter an apoptosis process, and causes reversible electroporation to occur in cells relatively far from the electrode needle;
• wherein the millisecond pulse sequence causes intracellular electrolysis of the cells relatively far from the electrode needle in which reversible electroporation occurs, such that the cells relatively far from the electrode needle also enter the apoptosis process.