Tissue closure systems

A tissue closure apparatus, comprising:

• a handle having one or more actuation mechanisms;
• a proximal catheter segment extending from the handle, wherein the proximal catheter segment further defines a proximal longitudinal axis;
• a deployment segment coupled to the proximal catheter segment;
• a distal catheter segment coupled to the deployment segment such that the distal catheter segment is rotatable at an angle relative to the proximal catheter segment, wherein the distal catheter segment further defines a distal longitudinal axis which is offset relative to the proximal longitudinal axis such that the distal longitudinal axis and the proximal longitudinal axis are non-collinear;
• a receiver member positioned within the deployment segment and having two or more openings along a first receiver portion and two or more openings along a second receiver portion, wherein the receiver member is configurable between a low-profile configuration and a deployed configuration;
• two or more forward needle members which are extendable distally from a first side of the proximal catheter segment and two or more rear needle members which are extendable distally from a second side of the proximal catheter segment opposite to the first side, and
• wherein the two or more forward needle members are receivable into the two or more openings along the first receiver portion and the two or more rear needle members are receivable into the two or more openings along the second receiver portion when the receiver member is in the deployed configuration.