US 12,663,429 B2Granted

Cartridge device for a measuring system for measuring viscoelastic characteristics of a sample liquid, a corresponding measuring system, and a corresponding method

AssigneeC A Casyso GmbH

InventorsAxel Schubert, Jose J. Romero-Galeano, Max Kessler

Life of this patent

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Abstract

The present invention is directed to a cartridge device for a measuring system for measuring viscoelastic characteristics of a sample liquid, in particular a blood sample, comprising a cartridge body having at least one measurement cavity formed therein and having at least one probe element arranged in said at least one measurement cavity for performing a test on said sample liquid; and a cover being attachable on said cartridge body; wherein said cover covers at least partially said at least one measurement cavity and forms a retaining element for retaining said probe element in a predetermined position within said at least one measurement cavity. The invention is directed to a measurement system and a method for measuring viscoelastic characteristics of a sample liquid.

Claims20

Dependent claims

A cartridge configured to couple to a system, the system being configured to determine at least one viscoelastic property associated with portions of a test sample, the cartridge comprising:

a plurality of measurement cavities, including a first measurement cavity and a second measurement cavity;
a plurality of receiving cavities, including a first receiving cavity to receive a first portion of the test sample and a second receiving cavity to receive a second portion of the test sample, the first receiving cavity being empty prior to receiving the first portion of the test sample, and the second receiving cavity being empty prior to receiving the second portion of the test sample;
a first fluid pathway fluidically connecting the first measurement cavity and the first receiving cavity, the first fluid pathway to transport the first portion of the test sample from the first receiving cavity to mix with a first reagent or combination of reagents;
and
a second fluid pathway fluidically connecting the second measurement cavity and the second receiving cavity, the second fluid pathway to transport the second portion of the test sample from the second receiving cavity to mix with a second reagent or combination of reagents;
wherein the first measurement cavity is configured to receive a first mixture based the first portion of the test sample and the first reagent or combination of reagents, the first measurement cavity being configured to enable the system to determine at least one first viscoelastic property based on the first mixture;
and
wherein the second measurement cavity is configured to receive a second mixture based the second portion of the test sample and the second reagent or combination of reagents, the second measurement cavity being configured to enable the system to determine at least one second viscoelastic property based on the second mixture.

5 more elements

A method of performing viscoelastic testing using a cartridge coupled to a measuring system, the method comprising:

performing first operations comprising:
receiving a first portion of a test sample in a first receiving cavity on the cartridge, the first receiving cavity being empty prior to receiving the first portion of the test sample;
transporting the first portion of the test sample out of the first receiving cavity and along a first fluid flow path to a location containing a first reagent or combination of reagents, the first portion of the test sample mixing with the first reagent or combination of reagents during transport;
transporting, to a first measurement cavity along the first fluid flow path, a first mixture that is based on the first portion of the test sample and the first reagent or combination of reagents;
and
performing a first viscoelastic test on the first mixture in the first measurement cavity;
performing second operations comprising:
receiving a second portion of the test sample in a second receiving cavity on the cartridge, the second receiving cavity being empty prior to receiving the second portion of the test sample;
transporting the second portion of the test sample out of the second receiving cavity and along a second fluid flow path to a location containing a second reagent or combination of reagents, the second portion of the test sample mixing with the second reagent or combination of reagents during transport;
transporting, to a second measurement cavity along the second fluid flow path, a second mixture that is based on the second portion of the test sample and the second reagent or combination of reagents;
and
performing a second viscoelastic test on the second mixture in the second measurement cavity.

9 more elements

Dependencies are inferred from the claim text.

Facts

Application: 18/891,832Filed 20 Sep 2024 · continuation
Priority: 23 Dec 2008
Published: US 2025/0027959 A123 Jan 2025
Granted: 23 Jun 2026
Term ends: Not estimatedThe source records don’t support an estimate.

Classification17 codes

G01N 33/86
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing:…
B01L 3/502
Containers for the purpose of retaining a material to be analysed, e.g. test tubes: with fluid transport, e.g. in multi-compartment structures
B01L 3/52
Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers: containers specially adapted for storing or dispensing a reagent
G01N 11/00
Investigating flow properties of materials

Family

Application61/140,344Us provisional application · filed 23 Dec 2008
Application12/640,376Parent of this continuation · filed 17 Dec 2009
Application13/895,034Parent of this continuation · filed 15 May 2013
US 8,448,499 B2Parent of this continuation · filed 28 May 2013
Application15/066,605Parent of this continuation · filed 10 Mar 2016
US 9,285,377 B2Parent of this continuation · filed 15 Mar 2016
Application15/357,492Parent of this continuation · filed 21 Nov 2016
US 9,739,789 B2Parent of this continuation · filed 22 Aug 2017
Application15/869,782Parent of this continuation · filed 12 Jan 2018
US 9,915,671 B2Parent of this continuation · filed 13 Mar 2018
Application16/146,333Parent of this continuation · filed 28 Sep 2018
Application16/520,004Parent of this continuation · filed 23 Jul 2019
US 10,746,750 B2Parent of this continuation · filed 18 Aug 2020
Application17/182,502Parent of this continuation · filed 23 Feb 2021
US 10,996,230 B2Parent of this continuation · filed 4 May 2021
Application17/372,637Parent of this continuation · filed 12 Jul 2021
US 11,061,038 B2Parent of this continuation · filed 13 Jul 2021
Application17/831,845Parent of this continuation · filed 3 Jun 2022
US 11,360,106 B2Parent of this continuation · filed 14 Jun 2022
Application18/212,002Parent of this continuation · filed 20 Jun 2023
US 11,768,211 B2Parent of this continuation · filed 26 Sep 2023
US 2025/0027959 A1Pre-grant publication · published 23 Jan 2025
US 12,111,326 B2Parent of this continuation
US 2010/0154520 A1Published application
US 2013/0323847 A1Published application
US 2016/0195557 A1Published application
US 2017/0097367 A1Published application
US 2018/0149664 A1Published application
US 2019/0195898 A1Published application
US 2019/0353672 A1Published application
US 2021/0172966 A1Published application
US 2021/0341499 A1Published application
US 2022/0365104 A1Published application
US 2024/0027477 A1Published application
US 12,663,429 B2This patent

From the US filing history. Foreign family members aren’t listed.