Antibody specifically binding to WRS protein, and use thereof
AssigneeJw Bioscience
InventorsSumi Bae, Sunghwa Son, Yunsun Kim, Jieun Park, Min Chul Park, Su Jin Kang
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Abstract
The present invention relates to an antibody specifically binding to a tryptophanyl-tRNA synthetase (WRS) protein and, more specifically, to: an antibody, or a fragment of the antibody, specifically binding to a polypeptide of an amino acid sequence represented by SEQ ID NO: 2 in a WRS protein; a polynucleotide encoding the antibody and a vector comprising same; a cell transformed using same; and a use thereof.
Claims7
An antibody or antigen binding fragment thereof which specifically binds to a polypeptide comprising the amino acid sequence of SEQ ID NO:
- 2 in a WRS (tryptophanyl-tRNA synthetase) protein, the antibody or antigen binding fragment thereof comprising a light-chain variable region (VL) comprising a complementarity determining region (CDR) L1 comprising the amino acid sequence of SEQ ID NO:
- 3, a complementarity-determining region (CDR) L2 comprising the amino acid sequence of SEQ ID NO:
- 4, and a complementarity-determining region (CDR) L3 comprising the amino acid sequence of SEQ ID NO:
- 5, and a heavy-chain variable region (VH) comprising a complementarity-determining region (CDR) H1 comprising the amino acid sequence of SEQ ID NO:
- 6, a complementarity-determining region (CDR) H2 comprising the amino acid sequence of SEQ ID NO:
- 7, and a complementarity-determining region (CDR) H3 comprising the amino acid sequence of SEQ ID NO:
- 8.
A composition comprising:
- an antibody or antigen binding fragment thereof which specifically binds to a polypeptide comprising the amino acid sequence of SEQ ID NO:
- 2 in a WRS (tryptophanyl-tRNA synthetase) protein, the antibody or antigen binding fragment thereof comprising a light-chain variable region (VL) comprising a complementarity determining region (CDR) L1 comprising the amino acid sequence of SEQ ID NO:
- 3, a complementarity-determining region (CDR) L2 comprising the amino acid sequence of SEQ ID NO:
- 4, and a complementarity-determining region (CDR) L3 comprising the amino acid sequence of SEQ ID NO:
- 5, and a heavy-chain variable region (VH) comprising a complementarity-determining region (CDR) H1 comprising the amino acid sequence of SEQ ID NO:
- 6, a complementarity-determining region (CDR) H2 comprising the amino acid sequence of SEQ ID NO:
- 7, and a complementarity-determining region (CDR) H3 comprising the amino acid sequence of SEQ ID NO:
- 8;
- and
- an excipient.
A method of detecting WRS protein in a sample, comprising:
- a) Obtaining the sample from a subject;
- b) Contacting the sample with an antibody or antigen binding fragment thereof, wherein the antibody or antigen binding fragment thereof is labeled with a detectable moiety;
- and
- c) Detecting WRS protein in the sample by detecting a signal from the detectable moiety;
- wherein the antibody or antigen binding fragment thereof specifically binds to a polypeptide comprising the amino acid sequence of SEQ ID NO:
- 2 in a WRS (tryptophanyl-tRNA synthetase) protein, and wherein the antibody or antigen binding fragment thereof comprises a light-chain variable region (VL) comprising a complementarity determining region (CDR) L1 comprising the amino acid sequence of SEQ ID NO:
- 3, a complementarity-determining region (CDR) L2 comprising the amino acid sequence of SEQ ID NO:
- 4, and a complementarity-determining region (CDR) L3 comprising the amino acid sequence of SEQ ID NO:
- 5, and a heavy-chain variable region (VH) comprising a complementarity-determining region (CDR) H1 comprising the amino acid sequence of SEQ ID NO:
- 6, a complementarity-determining region (CDR) H2 comprising the amino acid sequence of SEQ ID NO:
- 7, and a complementarity-determining region (CDR) H3 comprising the amino acid sequence of SEQ ID NO:
- 8.
Dependencies are inferred from the claim text.