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US 12,662,679 B2Granted
Production of fatty acid derivatives
AssigneeGenomatica, Inc.
InventorsDerek L. Greenfield, Andreas W. Schirmer, Elizabeth J. Clarke, Eli S. Groban, Bernardo M. Da Costa, Zhihao Hu, Kevin Holden, Noah Helman
Life of this patent
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Abstract
The disclosure relates to recombinant host cells including strain modifications effective to improve titer, yield and/or productivity of fatty acid derivatives. The disclosure further relates to cell cultures including the recombinant host cells for the fermentative production of fatty acid derivatives and compositions thereof.
Claims9
A recombinant bacterial host cell expressing a polypeptide having 3-hydroxy-acyl-[acp] dehydratase activity;
- wherein the polypeptide having 3-hydroxy-acyl-[acp] dehydratase activity is FabA;
- wherein the recombinant bacterial host cell expresses one or more additional polypeptides, and the one or more additional polypeptides are FabV, FabH, FabD, FabG, and FabF;
- and
- wherein the recombinant bacterial host cell produces a fatty acid derivative composition at a higher titer, yield, or productivity than a corresponding wild-type host cell when cultured in a medium containing a carbon source.
1 more element
Dependencies are inferred from the claim text.