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US 12,662,678 B2Granted
Binding molecule binding to traumatic brain injury-associated tau and methods of use thereof
AssigneeArizona Board of Regents on behalf of Arizona State University
InventorsMichael Sierks, Lalitha Venkataraman, Wei Xin
Life of this patent
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Abstract
The present invention provides detection reagents and method for determining risk of traumatic brain injury (TBI) and/or susceptibility to neurodegenerative disease in a subject.
Claims14
A binding molecule, wherein the binding molecule preferentially recognizes human traumatic brain injury (TBI)-associated tau relative to tau from a healthy normal control and comprises an amino acid sequence at least 96% identical to:
- (a) an antibody heavy chain variable domain and light chain variable domain of SEQ ID NO:42, or (b) a designed ankyrin repeat protein (DARPin) of SEQ ID NO:44, SEQ ID NO:48, SEQ ID NO:52, or SEQ ID NO:54;
- wherein differences from the heavy chain variable domain and light chain variable domain of (a) or the DARPIN of (b) are conservative substitutions.
Dependencies are inferred from the claim text.