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US 12,662,626 B2Granted
Dicationic fluorescent dyes
AssigneeRoche Molecular Systems, Inc.
InventorAlexander Nierth
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Abstract
The present invention provides for water-soluble mono- and dicationic fluorescent dyes with the latter exhibiting stable fluorescence at elevated temperatures. The present invention also provides for methods for the production of the fluorescent dyes and for using these dyes in biological assays such as multiplexing qPCR and tissue staining.
Claims13
A fluorescent dye of Formula A or B
- wherein:
- X=Si, Ge, or C;
- Y=Me, Et, iPr, or Ph;
- Z=any one of:
- W=any one of:
- R1 and R2 are any combination of:
- and L=H, SO3H, CONH2, CO2H, N3, or a moiety subject to click chemistry functionality selected from the group consisting of an alkyne and an azide.
4 more elements
Dependencies are inferred from the claim text.