Temperature-insensitive membrane materials and analyte sensors containing the same

An in vivo analyte sensor for measuring analyte concentration in a bodily fluid of a user, the analyte sensor comprising:

• a first portion positionable above a surface of a skin coupled with an analyte monitoring system, the analyte monitoring system comprising a sensor control device configured to determine data indicative of analyte concentration and to transmit the data indicative of analyte concentration to a reader device according to an electronic communication protocol via a transmitter coupled to the sensor control device, and a power source for operating the sensor control device,
• a second portion positionable below the surface of the skin, wherein the second portion is in contact with bodily fluid and configured to monitor analyte concentration in the bodily fluid, the second portion comprising a working electrode connected to contacts positioned on the first portion, wherein the working electrode comprises at least one sensing region;
• wherein each sensing region comprises:
• an analyte-responsive enzyme;
• a counter electrode;
• and
• a polymeric membrane material overcoating the sensing region;
• wherein the polymeric membrane material comprises a polymer backbone comprising one or more side chains that comprise a heterocycle, and an amine-free polyether arm appended, via an alkyl spacer or a hydroxy-functionalized alkyl spacer, to the heterocycle of at least a portion of the one or more side chains;
• and
• wherein the amine-free polyether arm of the polymeric membrane material has a structure of Formula 13:
• wherein w is 0 or 1, x ranges between about 4 and about 24, y ranges between about 8 and about 60, and z ranges between about 6 and about 36.