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AssigneeChugai Seiyaku Kabushiki Kaisha
InventorsTetsuhiro Soeda, Jinki Hadano
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Production was attempted for antibodies that neutralize the activity of a bispecific antibody having F.VIII function-substituting activity, for use in a method for measuring the reactivity of F.VIII in the presence of a bispecific antibody having F.VIII function-substituting activity. As a result, it was discovered that by using the produced antibodies, F.VIII activity in the plasma of a hemophilia A patient can be evaluated accurately by performing APTT-based one-stage clotting assay on a wide range of bispecific antibodies having F.VIII function-substituting activity. It was also discovered that F.VIII inhibitor titer in the plasma of a hemophilia A patient carrying F.VIII inhibitor can be evaluated accurately by APTT-based Bethesda assay.
An antibody that comprises a heavy chain variable region comprising the amino acid sequence of SEQ ID NO:
An antibody that comprises an antibody heavy chain comprising the amino acid sequence of SEQ ID NO:
An antibody that comprises a heavy chain variable region comprising the amino acid sequence of SEQ ID NO:
An antibody that comprises an antibody heavy chain comprising the amino acid sequence of SEQ ID NO:
An antibody comprising:
An antibody comprising:
Dependencies are inferred from the claim text.