Stable formulations of immunoglobulin single variable domains

A formulation comprising a von Willebrand Factor (vWF) binder, a citrate buffer, an excipient, and polysorbate 80, wherein:

• (a) the vWF binder has a concentration from about 0.1 mg/mL to about 80 mg/mL;
• (b) the excipient is sucrose at a concentration of about 5% to about 15% (w/v);
• (c) the polysorbate 80 has a concentration of about 0.001% to 0.5% (v/v), wherein the polysorbate 80 does not have a concentration of about 0.01% (w/v);
• and
• (d) the citrate buffer has a concentration of about 5 mM to about 200 mM such that the pH of the formulation is about 6.0 to about 7.0,
• wherein said vWF binder comprises at least one of SEQ ID NOs:
• 1-19.

A formulation comprising a von Willebrand Factor (vWF) binder, a citrate buffer, an excipient, and polysorbate 80, wherein:

• (a) the vWF binder has a concentration from about 0.1 mg/mL to about 80 mg/mL;
• (b) the excipient is sucrose at a concentration of about 5% to about 15% (w/v);
• (c) the polysorbate 80 has a concentration of about 0.001% to 0.5% (v/v);
• and
• (d) the citrate buffer has a concentration of about 5 mM to about 200 mM such that the pH of the formulation is about 6.0 to about 7.0, wherein the citrate buffer does not have a concentration of about 20 mM,
• wherein said vWF binder comprises at least one of SEQ ID NOs:
• 1-19.