Chimeric polypeptides and uses thereof
AssigneesGenethon, Universite D'Evry Val D'Essonne, Inserm (Institut National De La Sante Et De La Recherche Medicale), Sorbonne Universite
InventorsPasqualina Colella, Francesco Puzzo, Federico Mingozzi
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Abstract
The present invention relates to a nucleic acid molecule encoding a chimeric polypeptide comprising a peptide of interest fused to one or more heterologous moieties, wherein at least one of the heterologous moieties is a ligand of the Sortilin receptor. The invention also relates to a chimeric polypeptide encoded by said nucleic acid molecule and uses thereof.
Claims13
A nucleic acid molecule encoding a chimeric polypeptide comprising a peptide of interest fused to one or more heterologous moieties, wherein at least one of the heterologous moieties is a ligand of the Sortilin receptor, and said heterologous moiety is
- a Spadin peptide encoded by the nucleotide sequence of SEQ ID NO:
- 14 or by a nucleotide sequence having at least 85% identity to the nucleotide sequence of SEQ ID NO:
- 14.
Dependencies are inferred from the claim text.