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US 12,662,509 B2Granted
Inhibitors of 17β-HSD7 and uses thereof
AssigneeShengXiang Lin
InventorsSheng-Xiang Lin, Donald Poirier, René Maltais, Jean-Yves Sancéau
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Abstract
Novel chemical agents are described herein. More specifically, a novel inhibitor of 17β-HSD7 for decreasing estradiol concentrations while restoring dihydrotestosterone (DHT) concentrations in breast cancer cells is disclosed herein. In a particular embodiment, the inhibitor of 17β-HSD7 has the following structure: (Formula I) A process for producing the novel inhibitors of 17β-HSD7 and their use in the manufacture of pharmaceutical formulations and/or combinations is also disclosed.
Claims20
A 17β-hydroxysteroid dehydrogenase 7 (17β-HSD7) inhibitor compound of Formula I:
- or a pharmaceutically acceptable salt or solvate thereof, wherein, R is C≤12 alkyl or C≤12 cycloalkyl;
- and X is O or S.
Dependencies are inferred from the claim text.