Phosphorus compounds and methods thereof

A method of synthesising a phosphorus compound of Formula (I), a salt, solvate or isomer thereof:

• wherein Y is selected from an optionally substituted C1-10 alkylene, optionally substituted C1-10 alkenylene, optionally substituted silylene, optionally substituted aminoylene, acylene, thioacylene, sulfinylene, sulfonylene, —P(O)(OZ)— or —P+(R9R10)—;
• Z is selected from H, optionally substituted alkyl or a metal cation;
• R1, R2, R7 and R8 are independently selected from oxo, halo, optionally substituted alkyl;
• optionally substituted alkenyl;
• optionally substituted haloalkyl;
• optionally substituted alkynyl;
• optionally substituted oxyalkyl;
• optionally substituted amino, optionally substituted thio, optionally substituted cycloalkyl, optionally substituted cycloalkenyl, optionally substituted heterocyclyl, optionally substituted heteroaryl, and optionally substituted aryl;
• wherein R1 and R5 can be linked to form an optionally substituted cycloalkyl;
• R3, R4, R5, and R6 are independently selected from H, oxo, halo, optionally substituted alkyl;
• optionally substituted alkenyl;
• optionally substituted haloalkyl;
• optionally substituted alkynyl;
• optionally substituted oxyalkyl;
• optionally substituted amino, optionally substituted thio, optionally substituted cycloalkyl, optionally substituted cycloalkenyl, optionally substituted heterocyclyl, optionally substituted heteroaryl, and optionally substituted aryl;
• R9 and R10 are independently selected from H, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted heterocycloyl, optionally substituted aryl, optionally substituted heteroaryl;
• the method comprising:
• a) reacting a compound of Formula (A) with a hypophosphite ester, acid, salt or solvate thereof and an optional organosilicon compound, the compound of Formula (A) is
• wherein Y is selected from an optionally substituted C1-10 alkylene, optionally substituted C1-10 alkenylene, optionally substituted silylene, optionally substituted amino, acylene, thioacylene, sulfinylene, sulfonylene, —P(O)(OZ)— or —P+(R13R14)—;
• wherein R1, R2, R7 and R8 are independently selected from oxo, halo, optionally substituted alkyl;
• optionally substituted alkenyl;
• optionally substituted haloalkyl;
• optionally substituted alkynyl;
• optionally substituted oxyalkyl;
• optionally substituted amino, optionally substituted thio, optionally substituted cycloalkyl, optionally substituted cycloalkenyl, optionally substituted heterocyclyl, optionally substituted heteroaryl, and optionally substituted aryl;
• wherein R1 and R8 can be linked to form an optionally substituted cyclo moiety;
• R3 and R5 are independently selected from H, oxo, halo, optionally substituted alkyl;
• optionally substituted alkenyl;
• optionally substituted haloalkyl;
• optionally substituted alkynyl;
• optionally substituted oxyalkyl;
• optionally substituted amino, optionally substituted thio, optionally substituted cycloalkyl, optionally substituted cycloalkenyl, optionally substituted heterocyclyl, optionally substituted heteroaryl, and optionally substituted aryl;
• and
• wherein R13 and R14 are independently selected from H, optionally substituted C1-C10 alkyl, optionally substituted C3-C10 cycloalkyl, optionally substituted C3-C10 heterocyclyl, optionally substituted aryl, or optionally substituted heteroaryl.