Benzazepine compounds, preparation method therefor and pharmaceutical use thereof
AssigneesShanghai Senhui Medicine Co., Ltd., Shanghai Shengdi Pharmaceutical Co., Ltd., Jiangsu Hengrui Pharmaceuticals Co., Ltd.
InventorsLingjian Zhu, Jianyu Shi, Changjin Ji, Bangjie Dong, Jian Huang
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Abstract
Benzazepine compounds, a preparation method therefor and pharmaceutical use thereof. Specifically, the present invention relates to a compound represented by formula II-1 or formula VIII-1, a pharmaceutical composition containing same, and pharmaceutical use thereof. The benzazepine compounds can be used for treating diseases associated with vasopressin receptors, in particular hypertension, heart disease, etc.
Claims19
A compound of formula II-1 or a pharmaceutically acceptable salt thereof,
- wherein,
- Q is
- wherein:
- L1 is —(CH2)m—, and the —(CH2)— is optionally replaced by a heteroatom selected from the group consisting of O, S and N;
- L2 is —(CH2)n—, and the —(CH2)— is optionally replaced by a heteroatom selected from the group consisting of O, S and N;
- m is selected from the group consisting of 0, 1, 2, 3, 4, 5 and 6;
- n is selected from the group consisting of 1, 2, 3, 4, 5 and 6;
- the —(CH2)— of L2 is optionally substituted with A;
- X is selected from the group consisting of O and S;
- R1 is selected from the group consisting of C1-6 alkyl, C3-8 cycloalkyl and 3-12 membered heterocyclyl;
- the C1-6 alkyl, C3-8 cycloalkyl and 3-12 membered heterocyclyl are optionally substituted with group B;
- R2 is selected from the group consisting of C1-6 alkyl, C3-8 cycloalkyl and 3-12 membered heterocyclyl;
- the C1-6 alkyl, C3-8 cycloalkyl and 3-12 membered heterocyclyl are optionally substituted with group B;
- R3 is selected from the group consisting of C1-6 alkyl, C3-8 cycloalkyl and 3-12 membered heterocyclyl;
- the C1-6 alkyl, C3-8 cycloalkyl and 3-12 membered heterocyclyl are optionally substituted with group B;
- or R1 and R2 or R2 and R3, together with the N atom to which they are attached, form a 3-12 membered heterocyclyl group containing 1-3 heteroatoms;
- the 3-12 membered heterocyclyl group is optionally substituted with group B;
- A is selected from the group consisting of H, —COOH, —NH2, —OH, halogen, cyano, nitro, oxo, C1-6 alkyl, C1-6 alkoxy, C3-8 cycloalkyl, 3-12 membered heterocyclyl, —COR4, —NHCOR4 and —OCOR4;
- the —NH2, C1-6 alkyl, C1-6 alkoxy, C3-8 cycloalkyl and 3-12 membered heterocyclyl are optionally substituted with R4;
- R4 is selected from the group consisting of halogen, —NH2, —OH, C1-6 alkyl, C1-6 alkoxy, C3-8 cycloalkyl and 3-12 membered heterocyclyl;
- the C1-6 alkyl, C1-6 alkoxy, C3-8 cycloalkyl and 3-12 membered heterocyclyl are optionally substituted with one or more groups selected from the group consisting of —COOH, —NH2, —OH, halogen, cyano, nitro, oxo, C1-6 alkyl and C1-6 alkoxy;
- group B is selected from the group consisting of H, —COOH, —NH2, —OH, halogen, cyano, nitro and oxo.
Dependencies are inferred from the claim text.