Inhibitors for programmed cell necrosis and preparation method therefor and use thereof

A compound represented by the following Formula (I-c), or pharmaceutically acceptable salts thereof,

• wherein:
• dashed line is a chemical bond or none;
• X is selected from the group consisting of CR2, NR, O, S, CR, and N;
• R is selected from the group consisting of H, D, and C1-C4 alkyl;
• R1 and R2 are each independently selected from the group consisting of H and C1-C4 alkyl;
• or R1 and R2 together form a structure of substituted or unsubstituted —(CH2)n—;
• wherein, n is 1, 2, 3, or 4;
• ring A is selected from the group consisting of substituted or unsubstituted C6-C10 aryl, and substituted or unsubstituted 5-12 membered heteroaryl;
• ring B is selected from the group consisting of substituted or unsubstituted C6-C10 aryl, and substituted or unsubstituted 5-12 membered heteroaryl,
• wherein the substituted means that at least one hydrogen atom in a group is substituted by one or more substituents selected from the group consisting of halogen, deuterium, C1-C6 alkoxy, halogenated C1-C6 alkoxy, methyl sulfonyl, —S(═O)2NH2, oxo(═O), —CN, hydroxyl, —NH2, carboxyl, C2-C6 amido (—C(—O)—N(Rc)2 or—NH—C(—O)(Rc), wherein Rc is H or C1-C5 alkyl), C1-C6 alkyl-(C2-C6 amido), and substituted or unsubstituted groups selected from the group consisting of C1-C6 alkyl, C3-C8 cycloalkyl, C1-C6 amino, C6-C10 aryl, 5-10 membered heteroaryl having 1-3 heteroatoms selected from N, S and O, 5-12 membered heterocyclyl having 1-3 heteroatoms selected from N, S and O, —(CH2)—C6-C10 aryl, and —(CH2)-(5-10 membered heteroaryl having 1-3 heteroatoms selected from N, S and O), and the substituents are selected from the group consisting of halogen, C1-C6 alkyl, C1-C6 alkoxy, oxo, —CN, —NH2, —OH, C6-C10 aryl, C1-C6 amino, C2-C6 amido, and 5-10 membered heteroaryl having 1-3 heteroatoms selected from N, S and O.