Degraders of cyclin-dependent kinase 12 (CDK12) and uses thereof

A compound of Formula (I):

• or a pharmaceutically acceptable salt, co-crystal, tautomer, stereoisomer, solvate, hydrate, polymorph, isotopically enriched derivative, or prodrug thereof, wherein:
• each instance of R1 is independently halogen, acyl, alkyl, alkenyl, alkynyl, carbocyclyl, heterocyclyl, aryl, heteroaryl, —CN, —ORD1, —N(RD1a)2, or —SRD1, wherein RD1 is hydrogen, acyl, alkyl, alkenyl, alkynyl, carbocyclyl, heterocyclyl, aryl, or heteroaryl;
• wherein each occurrence of RD1a is hydrogen, acyl, alkyl, alkenyl, alkynyl, carbocyclyl, heterocyclyl, aryl, or heteroaryl;
• or two instances of RD1a are taken together with their intervening atoms to form a heteroaryl ring;
• each instance of R2 is independently halogen, acyl, alkyl, alkenyl, alkynyl, carbocyclyl, heterocyclyl, aryl, heteroaryl, —CN, —ORD1, —N(RD1a)2, or —SRD1;
• R3 is hydrogen, acyl, alkyl, alkenyl, alkynyl, carbocyclyl, heterocyclyl, aryl, or heteroaryl;
• Ring A is of formula:
• RY is —SO2RY1, —P(═O)(RY2)2, or —C(═O)N(Ry3)=2;
• RY1 is C1-C6 alkyl;
• each instance of RY2 is C1-C6 alkyl;
• each instance of Ry3 is independently hydrogen or alkyl;
• w1 is 1;
• x is 0 or 1;
• y is 0 or 1;
• L1 is —NRA—;
• wherein RA is hydrogen;
• L2 is an unsubstituted C1-24 hydrocarbon chain, optionally wherein one or more chain atoms of the hydrocarbon chain are independently replaced with —C(═O)—, —O—, or —NRb—, wherein Rb is hydrogen, or
• l4 indicates the point of attachment to D, and lR indicates the point of attachment to the moiety of formula
• n1 is 1, 2, 3, 4, 5, or 6;
• n2 is 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10;
• and
• D is of the formula:
• wherein:
• XA is C(O) or C(R3A)2;
• R1A is halogen, —OH, C1-C6 alkyl, or C1-C6 alkoxy;
• each R3A is independently H or C1-C3 alkyl;
• R3′ is C1-C3 alkyl;
• each R4A is independently H or C1-C3 alkyl;
• or two R4A, together with the carbon atom to which they are attached, form C(O);
• R5A is H, C1-C3 alkyl, or halogen;
• m is 0 or 1;
• n is 0 or 1;
• and
• a1 is 0 or 1,
• or
• wherein:
• R2′ is halogen, —OH, C1-C6 alkyl, or C1-C6 alkoxy;
• R4′ is halogen, —OH, C1-C6 alkyl, or C1-C6 alkoxy;
• R5′ is halogen, —OH, C1-C6 alkyl, or C1-C6 alkoxy;
• n1 is 0 or 1;
• n2 is 0 or 1;
• and
• n3 is 0 or 1.