Dextrorphan prodrugs and processes for making and using them

A compound having the following general formula:

• where L1 is
• and L2 is absent, or
• Y1 and Y2 are independently either absent, or [A-X—Z]n
• where A and Z are independently selected for Y1 and Y2, and are, independent of each other, either absent or selected from —O—, —S—, or —(CR1R2)k—,
• and where X is —(CR1R2)—;
• J is [M-W]p
• where M is —(CR3R4)q—;
• and W is absent, or —O— or —S—
• R1 and R2 are each independently selected for Y1 and Y2, and are, independent of each other, selected from H, alkyl, aryl, alkylaryl, alkoxy, haloalkyl, or haloaryl
• R3 and R4 are each independently selected from H, alkyl, aryl, alkylaryl, alkoxy, haloalkyl, or haloaryl
• for each Y1 and Y2, n is independently an integer of 1-4
• for each repeating unit of [A-X—Z]n, when —(CR1R2)k— is present, k is independently an integer of 1-4,
• p and q are independently selected from 1-4
• G1m and G2m are independently absent, or selected independently of each other and, when present, each repeating subunit is independently selected from H, oxoacid, polyethylene glycol having from 2 to 5 ethylene oxide units, or a vitamin compound;
• where m is selected independently for G1 and G2, and is an integer of 1-4, except that m is 1 when G1 or G2 is a hydrogen atom;
• or a pharmaceutically acceptable salt thereof.