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US 12,662,455 B2Granted
Tetrahydrobenzo-quinoline sulfonamide derivatives useful as IgE modulators
AssigneeUcb Biopharma Srl
InventorsTimothy John Norman, Selvaratnam Suganthan, Jag Paul Heer, Zeshan Yousuf
Life of this patent
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Abstract
The present invention relates to tetrahydrobenzo-isoquinoline sulfonamide derivatives of formula (I), processes for preparing them, pharmaceutical compositions containing them and their use in treating disorders caused by IgE (such as allergic responses, non-allergic mast cell responses or certain autoimmune responses), and in particular disorders caused by the interaction of IgE with the FcεRI receptor.
Claims15
A compound of formula (I) or a pharmaceutically acceptable salt thereof:
- wherein
- R1 and R2 independently represent:
- Hydrogen;
- or NHC(O)NH—C1-6-alkyl;
- or NHSO2—C1-6-alkyl;
- or NHC(O)NH-heteroaryl optionally substituted with one or more R1a;
- or heteroaryl optionally substituted with one or more group selected from the group consisting of amino;
- C1-6-alkyl;
- C(O)O—C1-6-alkyl;
- nitrile;
- heteroaryl optionally substituted with one or more R1a;
- NH—C1-6-alkyl;
- NH—C1-6-heterocycloalkyl;
- NH—C3-9-cycloalkyl;
- NH-heteroaryl optionally substituted with one or more R1a;
- or NH-heteroaryl optionally substituted with one or more group selected from the group consisting of C1-6-alkyl;
- C1-6-hydroxyalkyl;
- C3-9-hydroxyheterocycloalkyl;
- heteroaryl optionally substituted with one or more R1a;
- or NHC(O)—C1-6-alkyl;
- or NHC(O)-heteroaryl optionally substituted with one or more R1a
- R1a represents a group selected from the group consisting of:
- Halogen;
- nitrile;
- C1-6-alkyl;
- C1-6-haloalkyl;
- C1-6-alkoxy;
- C1-6-haloalkoxy;
- C(O)O—C1-6-alkyl;
- and C(O) OH;
- R3 represents a group selected from the group consisting of:
- C1-6-alkyl optionally substituted with one or more R3a groups;
- C1-3-alkanediyl-C3-6-cycloalkyl optionally substituted with one or more R3a groups;
- C1-3-alkanediyl-C3-6-heterocycloalkyl optionally substituted with one or more R3a groups;
- C3-6-heterocycloalkyl optionally substituted with one or more R3a groups;
- and
- C3-6-cycloalkyl optionally substituted with one or more R3a groups;
- R3a represents a group selected from the group consisting of hydrogen;
- Halogen;
- C1-2-alkyl;
- hydroxy;
- and C1-2-alkoxy;
- and
- R4 represents:
- C3-6-cycloalkyl optionally substituted with one or more R4a group;
- or C1-6-alkanediyl-C3-6-cycloalkyl optionally substituted with one or more R4a group;
- or C1-6-alkanediyl-C3-6-heterocycloalkyl optionally substituted with one or more R4a group;
- R4a represents a group selected from the group consisting of hydroxy;
- Halogen;
- and C1-2-alkyl.
47 more elements
Dependencies are inferred from the claim text.