Hydroxy-pyridinaldoxime scaffolds
AssigneesCentre National De La Recherche Scientifique, Etat FrançAis, Service De Santé Des ArméEs RepréSéNté Par Le DéLéGué GéNéRal De L'armement, Universite De Strasbourg, University of Southampton
InventorsRachid Baati, Richard Brown, José Dias, Alex Maryan-Instone, Florian Nachon, Jagadeesh Yerri, Camille Voros
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Abstract
The present invention relates to a compound of formula (I). It also relates to a pharmaceutical composition comprising at least one compound of formula (I) and at least one pharmaceutically acceptable support. Finally, it relates to the use of such a compound as a medicine, preferably in the treatment of a nervous and/or respiratory failure due to intoxication with at least one organophosphorous nerve agent; in the treatment of neurological diseases such as Alzheimer's disease; and/or in the treatment of cancer.
Claims9
A compound, or a salt thereof, selected from the group consisting of:
- (Z)-6-(4-aminobutyl)-3-hydroxypicolinaldehyde oxime JY-69:
- and
- Tert-butyl(E)-4-(4-(5-hydroxy-6-((hydroxyimino)methyl)pyridin-2-yl)butyl)piperazine-1-carboxylate AMI 318:
Dependencies are inferred from the claim text.