Solid state forms of lucerastat and process for preparation thereof
AssigneeAssia Chemical Industries Ltd.
InventorsAnantha Rajmohan Muthusamy, Sundara Lakshmi Kanniah, Yogesh Dhananjay Wagh
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Abstract
The present disclosure encompasses solid state forms of Lucerastat, in embodiments crystalline Lucerastat: L-Pyroglutamic acid, crystalline Lucerastat: Salicylic acid, crystalline Lucerastat: Fumaric acid, crystalline Lucerastat: Benzoic acid and crystalline Lucerastat: o-Acetylsalicylic acid, solid state form thereof, processes for preparation thereof, and pharmaceutical compositions thereof.
Claims11
A crystalline Form LC-1 of L-pyroglutamic acid salt of Lucerastat, which is characterized by data selected from one or more of the following:
- a) an XRPD pattern having peaks at 10.1, 13.3, 16.3, 20.3 and 30.7 degrees 2-theta ±0.2 degrees 2-theta;
- and/or
- b) an XRPD pattern as depicted in FIG. 1.
A crystalline Form LC-2 of Salicylic acid salt of Lucerastat, which is characterized by data selected from one or more of the following:
- a) an XRPD pattern having peaks at 5.2, 16.6, 18.2, 22.3 and 23.7 degrees 2-theta ±0.2 degrees 2-theta;
- and/or
- b) an XRPD pattern as depicted in FIG. 2.
Dependencies are inferred from the claim text.