Apparatus, system, and method for automated filling of syringes

An apparatus for filling a plurality of syringes, the apparatus comprising:

• a housing;
• a push-pull mechanism disposed within the housing, the mechanism including a motor and configured to engage the plurality of syringes and independently advance or retract a plunger of each syringe within the plurality;
• a syringe locking mechanism coupled to the housing, the locking mechanism configured to engage and constrain all syringes in the plurality in six degrees of freedom so as to substantially prevent motion of all syringes in the plurality during a process of filling of one or more syringes in the plurality;
• a manifold engagement fixture mounted to the housing, the manifold engagement fixture including a cam mechanism having a lever means, the manifold engagement fixture configured to detachably engage two mating halves of a multi-port fluid manifold and bring them together to form a fluidic seal between the two halves by movement of the lever means;
• a processor disposed within the housing and operatively coupled to the push-pull mechanism, the processor configured to control operation of at least the push pull mechanism;
• and
• a touch screen coupled to housing and operably coupled to the processor, the touch screen configured for haptic input and display of information associated with operation of the apparatus, the touch screen configured to send signals to the processor encoding the haptic input and receive signals from the processor encoding information to be displayed.

An apparatus for filling a plurality of syringes contained in a syringe pack, the apparatus comprising:

• a housing;
• a push-pull mechanism disposed within the housing, the mechanism including a motor and configured to engage the plurality of syringes and independently advance or retract a plunger of each syringe within the plurality;
• a syringe locking mechanism coupled to the housing, the locking mechanism configured to engage the syringe pack and constrain all syringes in the plurality in at least three degrees of freedom so as to substantially prevent motion of all syringes in the plurality when during a process of filling of one or more syringes in the plurality;
• a manifold engagement fixture mounted to the housing, the engagement fixture including a cam mechanism having a lever means, the engagement fixture configured to detachably engage two mating halves of a multi-port fluid manifold and bring them together to form a fluidic seal between the two halves by movement of the lever means;
• a processor disposed within the housing and operatively coupled to the push-pull mechanism, the processor configured to control operation of at least the push pull mechanism;
• and
• a touch screen coupled to housing and operably coupled to the processor, the touch screen configured for haptic input and display of information associated with operation of the apparatus, the touch screen configured to send signals to the processor encoding the haptic input and receive signals from the processor encoding information to be displayed.

A multi-syringe structure for delivery of multiple fluids, the structure adapted for use with at least one of a fluid delivery apparatus or a filling apparatus, the structure comprising:

• a plurality of syringes, each syringe comprising a syringe body and a plunger having a plunger head;
• a plurality of rigid connecting struts, each connecting strut fixedly positioned between the bodies of two syringes in the plurality;
• and
• a rigid support flange fixedly coupled to a bottom portion of each syringe body, the support flange having locking features positioned at horizontal ends of the flange, the locking features configured to detachably engage a locking mechanism of the fluid delivery apparatus and when so engaged, the support flange and the locking features configured to fix each syringe of the plurality in place in three axes so that each syringe head of the plurality of syringes can be independently engaged by separate elements of the fluid delivery apparatus;
• and
• wherein the multi-syringe structure includes indicia encoding content information of at least one syringe of the plurality.

A multi-syringe structure for delivery of multiple fluids to a reaction vessel to create a customized fluid mixture within the vessel, the structure adapted for use with a delivery apparatus, the structure comprising:

• a plurality of syringes, each syringe comprising a syringe body and a plunger having a plunger head;
• a plurality of rigid connecting struts, each connecting strut fixedly positioned between the bodies of two syringes in the plurality;
• and
• a rigid support flange fixedly coupled a bottom portion of each syringe body, the support flange having locking features positioned at horizontal ends of the flange, the locking features configured to detachably engage a locking mechanism of the fluid delivery apparatus and when so engaged, the support flange and the locking features configured to fix each syringe of the plurality in place so that each syringe head of the plurality of syringes can be independently engaged by separate elements of the fluid delivery apparatus without having to realign the structure between fluid deliveries from different syringes in the plurality;
• and
• wherein the multi-syringe structure includes indicia encoding content information of each syringe of the plurality of syringes, the content information used by the delivery apparatus to control the delivery of fluid within at least one syringe of the plurality to the reaction vessel.