Brachytherapy device

A flexible bioresorbable brachytherapy device for application on a wound site in a subject, the device comprising:

• a sealed radioactive source having opposite first and second sides, wherein the sealed radioactive source comprises:
• a radioactive component comprising a plurality of radio-isotope particles dispersed within a carrier,
• a barrier surrounding the radioactive component providing the sealed radioactive source,
• wherein the barrier functions as a barrier, when implanted at the wound site, providing the sealed radioactive source for at least six half-lives of the plurality of radio-isotope particles,
• wherein the plurality of radio-isotope particles are physically maintained in place within the sealed source such that relative movement of the plurality of radio-isotope particles is minimized for at least six half lives of the plurality of radio-isotope particles,
• a bioresorbable shield in the form of a dehydrated hydrogel layer, wherein the bioresorbable shield is located on the first side of the sealed radioactive source, the bioresorbable shield configured to shield radioactivity when implanted at the wound site for at least six half-lives of the plurality of radio-isotope particles.