Implant applicators

A method of treatment of an ophthalmic disease, comprising administration of a drug by injection with an ophthalmic injector needle into an eye of a patient, the ophthalmic injector needle comprising:

• a substantially cylindrical body defining a longitudinal flow path therein, the body including a first end, a second end, an outer peripheral face and a bevel region, the longitudinal flow path extending from the first end to the second end;
• a first bevel of the bevel region having a first bevel angle with respect to the outer peripheral face and a primary bevel rotation angle with respect to a midline of a needle cross-section;
• and
• a second bevel of the bevel region extending from the first bevel to the first end, the second bevel:
• (1) including a tip of the ophthalmic injector needle,
• (2) having a second bevel angle with respect to the outer peripheral face, the second bevel angle greater than the first bevel angle, and
• (3) having a secondary bevel rotation angle with respect to the midline of the needle cross-section, that is different from the primary bevel rotation angle;
• the first bevel and the second bevel defining a first transition and a second transition therebetween,
• the bevel region having a tapered width, and
• the first transition and second transition longitudinally positioned between the tip of the ophthalmic injector needle and a location of a maximum width of the bevel region, and wherein a first length of the first bevel and a second length of the second bevel are configured based on a thickness of a biological membrane to prevent the first transition and the second transition from penetrating an outer layer of the biological membrane simultaneously as the tip penetrates an inner layer of the biological membrane when the ophthalmic injector needle is inserted through the biological membrane by having a ratio between the second length of the second bevel, as measured from the tip to the first transition and the second transition, and the first length of the first bevel, as measured from the first transition and the second transition to where the outer peripheral face and the bevel region meet, is between:
• 1:0.97 and 1:4.93.