Injection system and method

An injection system, comprising:

• an injection system body defining a proximal opening at a proximal end thereof and a distal needle interface at a distal end thereof;
• a proximal stopper member and a distal stopper member disposed in the injection system body, forming a proximal drug chamber between the proximal stopper member and the distal stopper member and a distal drug chamber between the distal stopper member and the distal end of the injection system body;
• a plunger member configured to be manipulated to insert the proximal stopper member relative to the injection system body;
• and
• a valve forming an openable barrier between the distal needle interface and at least a portion of the distal drug chamber,
• wherein the valve defines a distally facing funnel configured to guide a proximal end of the fluid conveying member through the central seal during assembly of the injection system.

An injection system, comprising:

• an injection system body defining a proximal opening at a proximal end thereof and a distal needle interface at a distal end thereof,
• a proximal stopper member and a distal stopper member disposed in the injection system body, forming a proximal drug chamber between the proximal stopper member and a distal stopper member and a distal drug chamber between the distal stopper member and the distal end of the injection system body;
• a plunger member configured to be manipulated to insert the proximal stopper member relative to the injection system body;
• an elongate fluid conveying member configured to at least partially pierce the distal stopper member to form a flow path from the distal drug chamber to the proximal drug chamber, the elongate fluid conveying member defining a circumferential shoulder;
• and
• an insert configured to be disposed in the distal stopper member,
• wherein the insert comprises a distally facing funnel and a pair of fingers configured to interfere with the circumferential shoulder on the elongate fluid conveying member to temporarily prevent distally directed motion of the distal stopper member relative to the elongate fluid conveying member while the flow path from the distal drug chamber to the proximal drug chamber is open
• wherein the pair of fingers are disposed proximally of the distally facing funnel.