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US 12,661,435 B2Granted
Medical instrument
AssigneeThe University of Tokyo
InventorsYuki Akagi, Yasutaka Anraku, Ichiro Sakuma, Hayato Laurence Mizuno
Life of this patent
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Abstract
In a medical instrument that is inserted into an affected area or tissue to perform treatment, a technique of delivering various drugs to a target site is desired. Provided is a medical instrument that is inserted into an affected area or tissue to perform treatment, wherein a drug-loaded nanostructure is covalently bound to the medical instrument via a photosensitive linker immobilized on the surface of at least a portion of the medical instrument.
Claims16
A medical instrument that is inserted into an affected area or tissue to perform treatment, wherein
- a drug-loaded nanostructure is covalently bound to the medical instrument via a photosensitive linker immobilized on the surface of at least a portion of the medical instrument;
- the photosensitive linker has a first functional group that forms a covalent bond with a terminal functional group on the surface of the nanostructure,
- the nanostructure is a polymeric micelle, and the polymeric micelle is configured to comprise a block copolymer comprising a hydrophilic polymer chain and a polymer chain and the polymeric micelle has a core-shell structure having a core portion comprising the polymer chain and a drug and a shell portion comprising the hydrophilic polymer chain.
Dependencies are inferred from the claim text.