Back to results
US 12,661,433 B2Granted
Bioengineered scaffolds for modulation of immune system and the uses thereof
AssigneesPresident and Fellows of Harvard College, The General Hospital Corporation
InventorsNisarg J. Shah, Angelo S. Mao, Matthew D. Kerr, David J. Mooney, David T. Scadden
Life of this patent
Estimating the term…
Abstract
The present invention provides compositions and methods that modulate the immune system in a subject.
Claims20
A composition for modulating the immune system in a subject, comprising:
- a porous scaffold comprising a click-hydrogel or a click-cryogel, wherein the porous scaffold comprises macropores having a diameter greater than about 20 μm;
- a growth factor comprising a bone morphogenetic protein-2 (BMP-2) present at between about 1 ng to about 1000 ng per scaffold or at about 0.03 ng/mm3 to about 350 ng/mm3 by volume of scaffold, and in an amount effective for inducing formation of a tissue or an organ within the scaffold and recruiting a cell into the scaffold;
- and
- a differentiation factor comprising a Delta-like 4 (DLL-4) that induces the differentiation of the recruited cell into a T cell progenitor cell, wherein the T cell progenitor cell is capable of differentiating to a T cell.
1 more element
A method of modulating the immune system, reducing immune over-reactivity, increasing donor chimerism, and/or promoting balanced reconstitution of T cells of a human having a compromised immune system, comprising administering to the human a composition comprising:
- a porous scaffold comprising a click-hydrogel or a click-cryogel;
- a growth factor comprising a bone morphogenetic protein-2 (BMP-2) present in an amount effective for inducing formation of a tissue or an organ within the scaffold and recruiting a cell into the scaffold;
- and
- a differentiation factor comprising a Delta-like 4 (DLL-4) that induces the differentiation of the recruited cell into a T cell progenitor cell,
- thereby modulating the immune system of the human,
- wherein the human has a compromised immune system due to immunosenescence, congenital immunodeficiency, or acquired immunodeficiency.
3 more elements
Dependencies are inferred from the claim text.