Preparation method for non-spherical hydrogel microparticle embolic agent
AssigneeSouthern University of Science and Technology
InventorsQiongyu Guo, Yucheng Luo, Xingyu Jiang
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Abstract
A preparation method for a non-spherical hydrogel microparticle embolic agent is provided. The method includes: alternately injecting a oil phase solution and an aqeuous phase solution into an elongated channel, the aqueous phase solution contains a water-soluble polymer to be cross-linked, the aqueous phase solution has a cross-linking reaction in the elongated channel to obtain a product, which is then discharged from the elongated channel to obtain the non-spherical hydrogel microparticle embolic agent. This preparation method is simple in process, and the non-spherical hydrogel microparticle embolic agent obtained from this method has good embolization performance.
Claims15
A method for forming an embolic agent, comprising:
- obtaining an aqueous phase solution dissolved with a polymer to be cross-linked;
- obtaining an oil phase solution containing a water-soluble organic cross-linking agent;
- alternately injecting the oil phase solution and the aqueous phase solution into an elongated channel to form elongated droplets of the aqueous phase solution with uniform shape and size in the elongated channel, wherein the water-soluble organic cross-linking agent in the oil phase solution diffuses from the oil phase solution into the aqueous elongated droplets in the elongated channel, such that the water-soluble organic cross-linking agent and the polymer in the elongated droplets have a cross-linking reaction in the elongated channel to obtain solidified elongated and stable non-spherical hydrogel microparticles with uniform shape and size as the embolic agent;
- and
- discharging the embolic agent from the elongated channel.
Dependencies are inferred from the claim text.