Combinations of imaging agent conjugates and application thereof
AssigneeCuradel Surgical Innovations, Inc.
InventorsJohn V. Frangioni, Wolfgang Maison
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Abstract
The present invention provides a combination of two or more imaging agent conjugates comprising an imaging agent conjugated to a targeting ligand, wherein the imaging agent comprises one or more of ZW800-1, ZW830-1, ZW700-1-Forte, ZW-DOTA, ZW-PyC3A, ZW-Macropa, ZW-porphyrin, ZW-NOTA, and ZW-Deferoxamine; and the targeting ligand comprises one or more of a cRGD, a dPSMA-617 or a KUE, a FAP, a bombesin receptor binding vector, or a octreotide binding vector, or one or more of peptides selected from SEQ ID No: 1-4.
Claims6
A composition comprising a combination of imaging agents which absorb invisible near-infrared fluorescent light at the same wavelength;
- wherein the composition comprises a combination of:
- a) cRGD-ZW800-1, KUE-ZW800-1, and FAP-ZW800-1;
- b) cRGD-ZW700-1 Forte, KUE-ZW700-1 Forte, and FAP-ZW700-1 Forte;
- or
- c) cRGD-ZW830-1, KUE-ZW830-1, and FAP-ZW830-1.
Dependencies are inferred from the claim text.