Methods and materials for tissue ablation
AssigneesMayo Foundation for Medical Education and Research, President and Fellows of Harvard College
InventorsRahmi Oklu, Hassan Albadawi, Samir Mitragotri
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Abstract
This document relates to methods and materials for tissue ablation. For example, methods for using a composition including one or more ionic liquids (e.g., a composition including a LATTE solution) for tissue ablation are provided. In some cases, a composition including one or more ionic liquids (e.g., a composition including a LATTE solution) can be used to ablate tumor tissue within a mammal having cancer (e.g., to treat the mammal).
Claims20
A method for ablating at least a portion of a tissue within a mammal, wherein said method comprises percutaneously injecting a composition comprising an ionic liquid into said tissue within said mammal,
- wherein said ionic liquid comprises:
- (a) a cationic component comprising choline;
- and
- (b) an anionic component comprising geranate;
- wherein the composition does not comprise any additional therapeutic agent,
- wherein the choline and geranate are in a ratio of 1:1,
- wherein said composition is in the form of an aqueous solution or a hydrogel comprising a nanosilicate and is effective to create an ablation zone within said tissue,
- wherein when the composition is aqueous, the composition comprises 10-90% (w/w) of the choline geranate, and wherein said composition is effective to reduce the number of cells within said ablation zone.
A method for treating a mammal having cancer, wherein said method comprises percutaneously injecting a composition comprising an ionic liquid into a tumor tissue within said mammal,
- wherein said ionic liquid comprises:
- (a) a cationic component comprising choline;
- and
- (b) an anionic component comprising geranate;
- wherein the composition does not comprise any additional therapeutic agent,
- wherein the choline and geranate are in a ratio of 1:1,
- wherein said composition is in the form of an aqueous solution or a hydrogel comprising a nanosilicate and is effective to create an ablation zone within said tumor tissue,
- wherein when the composition is aqueous, the composition comprises 10-90% (w/w) of the choline geranate, and
- wherein said composition is effective to reduce the number of cancer cells within said ablation zone.
Dependencies are inferred from the claim text.